New Technology Permits Early-Stage Characterization and Preformulation Studies.
The complex 3-D structure of a protein ultimately determines its biological function. As such, maintaining the native conformation is clearly of critical importance if the protein in question is to be used as a therapeutic. Additionally, loss of higher order structure through complete unfolding or generation of partially folded intermediates can lead to rapid, irreversible aggregation, which can lead to problems ranging from loss of material during production to a raised immune response in patients.
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